UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells

Author:

Arndt Claudia12,Loureiro Liliana R.12,Feldmann Anja1,Jureczek Justyna34,Bergmann Ralf15ORCID,Máthé Domokos56,Hegedüs Nikolett5,Berndt Nicole1,Koristka Stefanie1,Mitwasi Nicola1,Fasslrinner Frederick7,Lamprecht Chris8,Kegler Alexandra13,Hoffmann Anja1,Bartsch Tabea1,Köseer Ayşe Sedef2,Egan Gary9,Schmitz Marc2310,Hořejší Vaclav11ORCID,Krause Mechthild23121314,Dubrovska Anna231213,Bachmann Michael1234ORCID

Affiliation:

1. Department of Radioimmunology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

2. National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany

3. German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany

4. UniversityCancerCenter (UCC), Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany

5. Semmelweis University, Department of Biophysics and Radiation Biology, Budapest, Hungary

6. CROmed Translational Research Centers, Budapest, Hungary

7. Medical Clinic and Polyclinic I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany

8. Department of Neurology, Center of Clinical Neuroscience, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany

9. Monash Biomedical Imaging, School of Psychological Sciences, and Australian Research Council Centre of Excellence for Integrative Brain Function, Monash University, Melbourne, Australia

10. Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany

11. Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic, Prague, Czech Republic

12. OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

13. Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology - OncoRay, Dresden, Germany

14. Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Funder

National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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