Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition

Author:

Eggink Florine A.1,Van Gool Inge C.2,Leary Alexandra3,Pollock Pamela M.4,Crosbie Emma J.5,Mileshkin Linda6,Jordanova Ekaterina S.27,Adam Julien3,Freeman-Mills Luke8,Church David N.89,Creutzberg Carien L.10,De Bruyn Marco1,Nijman Hans W.1ORCID,Bosse Tjalling2

Affiliation:

1. Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

2. Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands

3. Department of Medical Oncology, INSERM U981, Gustave Roussy Cancer Center, Villejuif, France

4. Queensland University of Technology (QUT), Translational Research Institute, Brisbane, QLD, Australia

5. Institute of Cancer Sciences, University of Manchester, St Marys Hospital, Manchester, UK

6. Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia

7. Center for Gynecological Oncology Amsterdam, VU Medical Center, Amsterdam, the Netherlands

8. Tumour Genomics and Immunology Group, Oxford Centre for Cancer Gene Research, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

9. Oxford Cancer Centre, Churchill Hospital, Oxford, UK

10. Department of Clinical Oncology, Leiden University Medical Center, Leiden, the Netherlands

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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