In-depth mechanistic analysis including high-throughput RNA sequencing in the prediction of functional and structural cardiotoxicants using hiPSC cardiomyocytes

Author:

Rosell-Hidalgo Alicia1,Bruhn Christopher2,Shardlow Emma1,Barton Ryan1,Ryder Stephanie1,Samatov Timur2,Hackmann Alexandra2,Aquino Gerald Ryan2,Fernandes Dos Reis Micael2,Galatenko Vladimir2,Fritsch Ruediger2,Dohrmann Cord2,Walker Paul A1ORCID

Affiliation:

1. Cyprotex Discovery Ltd UK, Macclesfield, UK

2. Evotec International GmbH, Göttingen, Germany

Funder

Evotec International GmbH

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

Reference160 articles.

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2. Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature;Onakpoya IJ;BMC Med,2016

3. The Non-Clinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals . 2005 [cited 2022]. Available from: http://www.ich.org/products/guidelines/safety/safety-single/article/safety-pharmacology-studies-for-humanpharmaceuticals.html.

4. The impact of drug-related QT prolongation on FDA regulatory decisions

5. Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels

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