Pharmacokinetics during therapeutic hypothermia in neonates: from pathophysiology to translational knowledge and physiologically-based pharmacokinetic (PBPK) modeling

Author:

Leys Karen1ORCID,Stroe Marina-Stefania2ORCID,Annaert Pieter13ORCID,Van Cruchten Steven2ORCID,Carpentier Sebastien4ORCID,Allegaert Karel5678ORCID,Smits Anne589ORCID

Affiliation:

1. Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences KU Leuven, Leuven, Belgium

2. Comparative Perinatal Development, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium

3. BioNotus GCV, Niel, Belgium

4. Facility for SYstems BIOlogy Mass Spectrometry, KU Leuven, Leuven, Belgium

5. Department of Development and Regeneration, KU Leuven, Leuven, Belgium

6. Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium

7. Department of Hospital Pharmacy, Erasmus MC, GA, Rotterdam, The Netherlands

8. Child and Youth Institute, KU Leuven, Leuven, Belgium

9. Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium

Funder

Research Foundation - Flanders

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

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