Xanthones from Securidaca inappendiculata antagonized the antirheumatic effects of methotrexate in vivo by promoting its secretion into urine.

Author:

Wang Dan-Dan1,Li Yan1,Wu Yi-Jin2,Wu Yi-Lai1,Han Jun3,Olatunji Opeyemi Joshua4ORCID,Wang Li5,Zuo Jian6ORCID

Affiliation:

1. Department of Traditional Chinese Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, China

2. Department of Pharmacy, The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China

3. Drug Research and Development Center, School of Pharmacy, Wannan Medical College, Wuhu, Anhui, China

4. Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Thailand

5. Department of Pharmacy, Wuhu Medicine and Health School, Wuhu, Anhui, China

6. Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, Wuhu, Anhui, China

Funder

the National Natural Science Foundation of China

Major Project of Natural Science Foundation of the Department of Education of Anhui province

‘Peak’ Training Program for Scientific Research of Yijishan Hospital, Wannan Medical College

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

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