Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

Author:

Lee Seung Yoon123,Jhun JooYeon123,Woo Jin Seok12,Lee Kun Hee123,Hwang Sun-Hee12,Moon Jeonghyeon4,Park Goeun5,Choi Sun Shim5,Kim So Jung6,Jung Yoon Ju7,Song Kyo Young6,Cho Mi-La1238ORCID

Affiliation:

1. Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea

2. Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea

3. Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea

4. Departments of Immunobiology and Neurology, Yale School of Medicine, New Haven, CT, USA

5. Division of Biomedical Convergence, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, Korea

6. Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

7. Division of Gastrointestinal Surgery, Department of Surgery, Yeouido St. Mary’s Hospital, Seoul, Korea

8. Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea

Funder

This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT)

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Gastroenterology,Microbiology

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