A patent review of MAT2a inhibitors (2018–2021)
Author:
Affiliation:
1. Oncology R&D, AstraZeneca, Cambridge UK
Funder
AstraZeneca
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/13543776.2022.2119127
Reference32 articles.
1. S-adenosylmethionine in Liver Health, Injury, and Cancer
2. Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis
3. Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
4. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
5. MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
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1. Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition;Journal of Biological Chemistry;2024-01
2. Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors;ACS Medicinal Chemistry Letters;2023-12-04
3. Amino acid metabolism in health and disease;Signal Transduction and Targeted Therapy;2023-09-13
4. Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability;Journal of Medicinal Chemistry;2023-03-24
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