Determination of Imatinib in the Blood Cells of Chronic Myelogenous Leukemia Patients by Ion-Trap Mass Spectrometry

Author:

Potěšil David,Stejskal Stanislav,Borský Marek,Šimara Pavel,Havelková Martina,Rázga Filip,Koutná Irena,Dvořáková Dana,Mayer Jiří,Ráčil Zdeněk,Zdráhal Zbyněk

Funder

This work was supported by the project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund, by the Czech Science Foundation (project no. P206/12/G151), by the Ministry of Education, Youth, and Sports of the Czech Republic (CZ.1.07/2.3.00/30.0030), by the Grant Agency of the Czech Republic (302/12/G157), and by the Czech Leukemia Study Group for Life (CELL).

Publisher

Informa UK Limited

Subject

Electrochemistry,Biochemistry (medical),Clinical Biochemistry,Spectroscopy,Biochemistry,Analytical Chemistry

Reference29 articles.

1. Part II: Management of resistance to imatinib in chronic myeloid leukaemia

2. Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia

3. Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

4. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

5. Busque , L. J. Chapdelaine , D. Desmarais , M. L. Coutu , and J.F. Larocque . 2009 . Development of high-throughput liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay to measure intracellular level of imatinib, N-desmethyl-Imatinib, and Nilotinib. InESH Eleventh International Conference Chronic Myeloid Leukaemia - Biological Basis of Therapy. Bordeaux, France.

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