A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Author:

Yang Hui-Li12,Lai Zhen-Zhen1,Shi Jia-Wei1,Zhou Wen-Jie3,Mei Jie4,Ye Jiang-Feng5,Zhang Tao6,Wang Jian1,Zhao Jian-Yuan78,Li Da-Jin1,Li Ming-Qing12ORCID

Affiliation:

1. Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, 200080 People’s Republic of China

2. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, 200080, People’s Republic of China

3. Center of Reproductive Medicine of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People’s Republic of China

4. Reproductive Medicine Center, Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medicine School, Nanjing, 210000, People’s Republic of China

5. Division of Obstetrics and Gynecology, KK Women’s and Children’s Hospital, 229899, Singapore

6. Assisted Reproductive Technology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, People’s Republic of China

7. State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, People’s Republic of China

8. Institute of Metabolism and Integrative Biology (IMIB), School of Life Sciences, Fudan University, Shanghai 200433, People’s Republic of China

Funder

Major Research Program of National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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