Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis

Author:

Yoshida Gota1,Kawabata Tsuyoshi12,Takamatsu Hyota3,Saita Shotaro14,Nakamura Shuhei14,Nishikawa Keizo56,Fujiwara Mari14,Enokidani Yusuke14,Yamamuro Tadashi14,Tabata Keisuke14,Hamasaki Maho14,Ishii Masaru5ORCID,Kumanogoh Atsushi3,Yoshimori Tamotsu14

Affiliation:

1. Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan

2. Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

3. Department of Respiratory Medicine, Allergy and Rheumatic Disease, Graduate School of Medicine, Osaka University, Osaka, Japan

4. Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

5. Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan

6. Faculty of Life and Medical Sciences, Department of Medical Life Systems, Doshisha University, Kyoto, Japan

Funder

HFSP and

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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