ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Author:

Deng Zhiqiang123,Lim Junghyun14,Wang Qian1,Purtell Kerry1ORCID,Wu Shuai5,Palomo Gloria M.6,Tan Haiyan7,Manfredi Giovanni6,Zhao Yanxiang5ORCID,Peng Junmin7ORCID,Hu Bo8,Chen Shi23,Yue Zhenyu1

Affiliation:

1. Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, China

3. Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China

4. Department of Cancer Immunology, Genentech Inc, South San Francisco, CA, USA

5. Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China

6. Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA

7. Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, TN, USA

8. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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