Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants

Author:

Eap C. B.12345ORCID,Gründer G.6ORCID,Baumann P.7ORCID,Ansermot N.1,Conca A.89,Corruble E.1011,Crettol S.1ORCID,Dahl M. L.12,de Leon J.13ORCID,Greiner C.14,Howes O.15,Kim E.1617,Lanzenberger R.18ORCID,Meyer J. H.19,Moessner R.20,Mulder H.21222324,Müller D. J.252627,Reis M.2829,Riederer P.3031,Ruhe H. G.3233ORCID,Spigset O.3435,Spina E.36ORCID,Stegman B.37,Steimer W.38,Stingl J.39,Suzen S.40,Uchida H.41,Unterecker S.42,Vandenberghe F.1ORCID,Hiemke C.43ORCID

Affiliation:

1. Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

2. Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

3. School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland

4. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland

5. Institute of Pharmaceutical Sciences of Western Switzerland, University of Lausanne, Switzerland, Geneva, Switzerland

6. Department of Molecular Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

7. Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

8. Department of Psychiatry, Health Service District Bolzano, Bolzano, Italy

9. Department of Child and Adolescent Psychiatry, South Tyrolean Regional Health Service, Bolzano, Italy

10. INSERM CESP, Team ≪MOODS≫, Service Hospitalo-Universitaire de Psychiatrie, Universite Paris Saclay, Le Kremlin Bicetre, France

11. Service Hospitalo-Universitaire de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France

12. Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

13. Eastern State Hospital, University of Kentucky Mental Health Research Center, Lexington, KY, USA

14. Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany

15. King’s College London and MRC London Institute of Medical Sciences (LMS)-Imperial College, London, UK

16. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea

17. Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea

18. Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

19. Campbell Family Mental Health Research Institute, CAMH and Department of Psychiatry, University of Toronto, Toronto, Canada

20. Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany

21. Department of Clinical Pharmacy, Wilhelmina Hospital Assen, Assen, The Netherlands

22. GGZ Drenthe Mental Health Services Drenthe, Assen, The Netherlands

23. Department of Pharmacotherapy, Epidemiology and Economics, Department of Pharmacy and Pharmaceutical Sciences, University of Groningen, Groningen, The Netherlands

24. Department of Psychiatry, Interdisciplinary Centre for Psychopathology and Emotion Regulation, University of Groningen, Groningen, The Netherlands

25. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada

26. Department of Psychiatry, University of Toronto, Toronto, ON, Canada

27. Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada

28. Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

29. Clinical Chemistry and Pharmacology, Skåne University Hospital, Lund, Sweden

30. Center of Mental Health, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany

31. Department of Psychiatry, University of Southern Denmark Odense, Odense, Denmark

32. Department of Psychiatry, Radboudumc, Nijmegen, the Netherlands

33. Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

34. Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway

35. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway

36. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

37. Institut für Pharmazie der Universität Regensburg, Regensburg, Germany

38. Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, Munich, Germany

39. Institute for Clinical Pharmacology, University Hospital of RWTH Aachen, Germany

40. Department of Toxicology, Faculty of Pharmacy, Ankara University, Ankara, Turkey

41. Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

42. Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany

43. Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany

Publisher

Informa UK Limited

Subject

Biological Psychiatry,Psychiatry and Mental health

Reference561 articles.

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2. ABCB1 Clinical Annotations. 2020. [accessed Oct 12]. https://www.pharmgkb.org/gene/PA267/clinicalAnnotation.

3. Age Effects on Alpha-1-Acid Glycoprotein Concentration and Imipramine Plasma Protein Binding

4. Abilify (aripiprazole) - FDA. 20XX Sunovion Pharmaceuticals Inc. 2002. [updated 2014 Dec; accessed 2020 Jun 27]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021436s038,021713s030,021729s022,021866s023lbl.pdf.

5. Is dose escalation of antidepressants a rational strategy after a medium–dose treatment has failed?

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