Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene BHLHE22

Author:

Hupalo Daniel1,Forsberg Christopher W.2,Goldberg Jack23,Kremen William S.45,Lyons Michael J.6,Soltis Anthony R.1,Viollet Coralie1,Ursano Robert J.7,Stein Murray B.4,Franz Carol E.4,Sun Yan V.8ORCID,Vaccarino Viola8,Smith Nicholas L.23,Dalgard Clifton L.19,Wilkerson Matthew D.19,Pollard Harvey B.19

Affiliation:

1. The American Genome Center, Collaborative Health Initiative Research Program, and Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, USA

2. Seattle Epidemiologic Research and Information Center, Office of Research and Development, U.S. Department of Veteran Affairs, Seattle, WA, USA

3. Department of Epidemiology, University of Washington, Seattle, WA, USA

4. Department of Psychiatry and of Family Medicine & Public Health, University of California, La Jolla, CA, USA

5. VA San Diego Center of Excellence for Stress and Mental Health, San Diego, CA, USA

6. Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA

7. Department of Psychiatry, Uniformed Services University, Bethesda, MD, USA

8. Department of Epidemiology, Emory University, Atlanta, GA, USA

9. Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, USA

Funder

NHLBI/NIH

Cooperative Studies Program (CSP) of the United States Department of Veterans Affairs (VA) Office of Research & Development;

Publisher

Informa UK Limited

Subject

Biological Psychiatry,Psychiatry and Mental health

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