Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure)

Author:

Stienen Susan1ORCID,Ferreira João Pedro12,Kobayashi Masatake1,Preud’homme Gregoire1,Dobre Daniela13,Machu Jean-Loup1,Duarte Kevin1,Bresso Emmanuel4,Devignes Marie-Dominique4,López Natalia5,Girerd Nicolas1,Aakhus Svend67,Ambrosio Giuseppe8,Brunner-La Rocca Hans-Peter9,Fontes-Carvalho Ricardo10,Fraser Alan G.11,van Heerebeek Loek12,Heymans Stephane131415,de Keulenaer Gilles16,Marino Paolo17,McDonald Kenneth18,Mebazaa Alexandre19,Papp Zoltàn20,Raddino Riccardo21,Tschöpe Carsten22,Paulus Walter J.23,Zannad Faiez1,Rossignol Patrick1

Affiliation:

1. CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), INSERM U1116, Centre d’Investigation Clinique et Plurithématique 1433, INSERM, Université de Lorraine, Nancy, France;

2. Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto, Portugal;

3. Clinical research and Investigation Unit, Psychotherapeutic Center of Nancy, Laxou, France;

4. Equipe CAPSID, LORIA (CNRS, Inria NGE, Université de Lorraine), Vandoeuvre-lès-Nancy, France;

5. Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain;

6. Department of Cardiology and Institute for Surgical Research, Oslo University Hospital, Oslo, Norway;

7. ISB, Norwegian University of Science and Technology, Trondheim, Norway;

8. Division of Cardiology, University of Perugia School of Medicine, Perugia, Italy;

9. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands;

10. Department of Surgery and Physiology, Cardiovascular Research Unit (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal;

11. Wales Heart Research Institute, Cardiff University, Cardiff, UK;

12. Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands;

13. Department of Cardiology, CARIM School for Cardiovascular Diseases Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands;

14. Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, Leuven, Belgium;

15. William Harvey Research Institute, Barts Heart Centre, Queen Mary University of London, London, UK;

16. Laboratory of Physiopharmacology, Antwerp University, and ZNA Hartcentrum, Antwerp, Belgium;

17. Clinical Cardiology, Università del Piemonte Orientale, Department of Translational Medicine, Azienda Ospedaliero Universitaria “Maggiore della Carità”, Novara, Italy;

18. School of Medicine and Medical Sciences, St Michael’s Hospital Dun Laoghaire Co. Dublin, Dublin, Ireland;

19. Department of Anaesthesiology and Critical Care Medicine, Saint Louis and Lariboisière University Hospitals and INSERM UMR-S 942, Paris, France;

20. Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;

21. Department of Cardiology, Spedali Civili di Brescia, Brescia, Italy;

22. Department of Cardiology, Campus Virchow-Klinikum, C, Harite Universitaetsmedizin Berlin, Berlin Institute of Health – Center for Regenerative Therapies (BIH-BCRT), and the German Center for Cardiovascular Research (DZHK; Berlin partner site), Berlin, Germany;

23. Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, the Netherlands

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Clinical Biochemistry,Biochemistry

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