Basis of Selectivity of Antibacterial Diaminopyrimidines

Author:

Baccanari D.P.1,Kuyper L.F.2

Affiliation:

1. Division of Molecular Genetics and Microbiology

2. Division of Organic Chemistry, Burroughs Wellcome Co, Research Triangle Park, NC 27709 (USA).

Publisher

Informa UK Limited

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Oncology

Reference28 articles.

1. Hitchings GH. Nobel lecture in physiology or medicine-1988: selective inhibitors of dihydrofolate reductase. In Vitro Cell Develop Biol 1989; 25: 303–10.

2. Blakley RL. Dihydrofolate reductase. In: Blakley RL, Benkovic SJ, eds. Chemistry and Biochemistry of Folates. New York: John Wiley & Sons, 1984: 191–253.

3. Burchall JJ, Hitchings GH. Inhibitor binding analysis of dihydrofolate reductases from various species. Mol Pharmacol 1965; 1: 126–36.

4. Baccanari DP, Daluge S, King RW. Inhibition of dihydrofolate reductase: effect of reduced nicotinamide adenine dinucleotide phosphate on the selectivity and affinity of diaminopyrimidines. Biochemistry 1982; 21: 5068–75.

5. Freisheim JH, Matthews DA. The comparative biochemistry of dihydrofolate reductase. In: Sirotnak FM, Burchall JJ, Ensminger WB, Montgomery JA, eds. Folate antagonists as therapeutic agents (Vol 1). New York: Academic Press, 1984: 69–131.

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