Nobiletin derivative, 5-acetoxy-6,7,8,3’,4’-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia-Reference-Cited by-同舟云学术

Nobiletin derivative, 5-acetoxy-6,7,8,3’,4’-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia

Published:2024-06-04 Issue:4 Volume:46 Page:450-460
ISSN:0892-3973
Container-title:Immunopharmacology and Immunotoxicology
language:en
Short-container-title:Immunopharmacology and Immunotoxicology

Author:

Chuang Jimmy Ming-Jung¹,Chen Hsien-Lin²,Chang Chi-I³,Lin Jia-Syuan⁴,Chang Hui-Min⁴,Wu Wan-Ju⁴,Lin Mei-Ying⁵,Chen Wu-Fu¹⁶,Lee Chien-Hsing³⁴⁷⁸

Affiliation:

1. Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan

2. Division of General Surgery, Department of Surgery, Chi Mei Medical Center, Liouying, Tainan, Taiwan

3. Department of Biological Science and Technology, National Pingtung University of Science and Technology, Research Centre for Active Natural Products Development, National Pingtung University of Science and Technology, Pingtung, Taiwan

4. Department of Pharmacology, School of Post-Baccalaureate Medicine; Division of Pharmacology and Traditional Chinese Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

5. Community Health Promotion Center, Kaohsiung Municipal Ci-Jin Hospital, Kaohsiung, Taiwan

6. Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan

7. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

8. Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

Funder

National Pingtung University of Science

Technology (NPUST)-Kaohsiung Medical University (KMU) Joint Research Project

KMU-KMUH Co-Project of Key Research

Kaohsiung Medical University

Chi-Mei Medical Center Liouying Research Grant

Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/08923973.2024.2360050

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4. Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells

5. Cleistocalyx nervosum var. paniala Berry Seed Protects against TNF-α-Stimulated Neuroinflammation by Inducing HO-1 and Suppressing NF-κB Mechanism in BV-2 Microglial Cells