PNP inhibitors selectively kill cancer cells lacking SAMHD1
Author:
Affiliation:
1. Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
2. InhaTarget Therapeutics, Gosselies, Belgium
Funder
Medical Research Council
MRC Human Immunology Unit core funding
Wellcome Trust
Publisher
Informa UK Limited
Subject
Cancer Research,Molecular Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/23723556.2020.1804308
Reference10 articles.
1. SAMHD1 Functions and Human Diseases
2. SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP
3. SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage
4. Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes
5. Deoxyguanosine is a TLR7 agonist
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