Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents-Reference-Cited by-同舟云学术

Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents

Published:2021-01-01 Issue:1 Volume:36 Page:1312-1332
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Shawky Ahmed M.¹²,Ibrahim Nashwa A.³⁴,Abdalla Ashraf N.⁵⁶,Abourehab Mohammed A. S.⁷⁸,Gouda Ahmed M.³⁴^ORCID

Affiliation:

1. Science and Technology Unit (STU), Umm Al-Qura University, Makkah, Saudi Arabia

2. Central Laboratory for Micro-analysis, Minia University, Minia, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

4. Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

6. Department of Pharmacology and Toxicology, Medicinal and Aromatic Plants Research Institute, National Center for Research, Khartoum, Sudan

7. Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

8. Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.1937618

Reference41 articles.

1. Cancer statistics, 2019

2. Drug Resistance in Cancer: An Overview

3. Combination therapy in combating cancer

4. Combination Therapy and the Evolution of Resistance: The Theoretical Merits of Synergism and Antagonism in Cancer

5. Multi-Targeted Anticancer Agents

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