Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N -(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

Author:

Al-Karmalawy Ahmed A.1ORCID,El-Gamil Dalia S.1,El-Shesheny Rabeh2,Sharaky Marwa3,Alnajjar Radwan456,Kutkat Omnia2,Moatasim Yassmin2,Elagawany Mohamed7,Al-Rashood Sara T.8,Binjubair Faizah A.8,Eldehna Wagdy M.910ORCID,Noreddin Ayman M.1112,Zakaria Mohamed Y.13

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt

2. Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, Egypt

3. Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt

4. Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya

5. Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya

6. Department of Chemistry, University of Cape Town, Rondebosch, South Africa

7. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt

8. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

9. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

10. School of Biotechnology, Badr University in Cairo, Badr City, Egypt

11. Department of Internal Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA

12. Department of Clinical Pharmacy, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt

13. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, Egypt

Funder

King Saud University, Riyadh, Saudi Arabia

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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