Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers-Reference-Cited by-同舟云学术

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

Published:2023-08-18 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

El-Kalyoubi Samar¹,Khalifa Mohamed M.²,Abo-Elfadl Mahmoud T.³⁴,El-Sayed Ahmed A.⁵,Elkamhawy Ahmed⁶⁷,Lee Kyeong⁶,Al-Karmalawy Ahmed A.⁸^ORCID

Affiliation:

1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt

2. Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

3. Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt

4. Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt

5. Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Giza, Egypt

6. College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University—Seoul, Goyang, Republic of Korea

7. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

8. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt

Funder

National Research Foundation of Korea (NRF) Grant

Korean Government

BK21 FOUR Program

Ministry of Education of Korea through NRF

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2242714

Reference77 articles.

1. Why is cancer drug discovery so difficult?

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3. The structural basis for cancer treatment decisions

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