Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with <i>in vivo</i> proof-Reference-Cited by-同舟云学术

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Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof

Published:2024-01-30 Issue:1 Volume:39 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

El-Miligy Mostafa M. M.¹^ORCID,Al-Kubeisi Ahmed K.²,Nassra Rasha A.³,El-Zemity Saad R.⁴,Hazzaa Aly A.¹

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

2. Pharmacy Department, Al-Maarif University College, Ramadi, Anbar, Iraq

3. Medical Biochemistry Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

4. Department of Chemistry and Technology of Pesticides, Faculty of Agriculture, Alexandria University, Alexandria, Egypt

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2024.2309171

Reference71 articles.

1. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

2. The structures of prostaglandin endoperoxide H synthases-1 and -2

3. Selective cox-2 inhibitors: a review of their structure-activity relationships;Zarghi A;Iran J Pharm Res,2011

4. Prostaglandins as mediators of cox-2 derived carcinogenesis in gastrointestinal tract;Konturek P;J Physiol Pharmacol,2005

5. Prostaglandin endoperoxide synthase: why two isoforms?;Williams CS;Am J Physiol,1996

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