Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)
Author:
Affiliation:
1. Université de Paris, Faculté de Pharmacie de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM, Paris, France
2. Service biologie du médicament, toxicologie, AP-HP, Hôpital Cochin, Paris, France
Funder
University Paris Descartes
French CNRS
French INSERM
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1758691
Reference93 articles.
1. Sirtuins in Epigenetic Regulation
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3. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in theSIRT1gene
4. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
5. A therapeutic role for sirtuins in diseases of aging?
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