Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice

Author:

Kunze Sarah1ORCID,Cecil Alexander2ORCID,Prehn Cornelia2ORCID,Möller Gabriele2ORCID,Ohlmann Andreas3ORCID,Wildner Gerhild3,Thurau Stephan3,Unger Kristian4ORCID,Rößler Ute5,Hölter Sabine M.1ORCID,Tapio Soile67ORCID,Wagner Florian8,Beyerlein Andreas9ORCID,Theis Fabian9ORCID,Zitzelsberger Horst4ORCID,Kulka Ulrike5ORCID,Adamski Jerzy21011ORCID,Graw Jochen1ORCID,Dalke Claudia1ORCID

Affiliation:

1. Institute of Developmental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany

2. Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany

3. Department of Ophthalmology, University Hospital, Ludwig-Maximilians University, Munich, Germany

4. Research Unit Radiation Cytogenetics, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany

5. Department Radiation Protection and Health, Federal Office of Radiation Protection, Oberschleissheim, Germany

6. Institute of Radiation Biology, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany

7. School of Medicine, Technical University of Munich, Munich, Germany

8. Institute of Radiation Medicine, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany

9. Institute of Computational Biology, Neuherberg, Germany

10. Lehrstuhl für Experimentelle Genetik, Technical University of Munich, Freising-Weihenstephan, Germany

11. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Funder

German Federal Ministry of Education and Research

Euratom research and training programme

CONCERT

Publisher

Informa UK Limited

Subject

Radiology Nuclear Medicine and imaging,Radiological and Ultrasound Technology

Reference62 articles.

1. European Medicines Agency [EMA]. 2009. Committee for Medicinal Products for Human Use (CHMP). Guideline on bioanalytical method validation. EMEA/CHMP/EWP/192217/2009 Rev. 1 Corr. 2, 21 July 2011. https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf.

2. Principal component analysis

3. Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research

4. Risk of various types of cataracts in a cohort of Mayak workers following chronic occupational exposure to ionizing radiation

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