Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors
Author:
Affiliation:
1. Department of Immunology, Gynecologic Oncology and Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA
2. Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA
Funder
National Cancer Institute
Publisher
Informa UK Limited
Subject
General Medicine,Immunology
Link
https://www.tandfonline.com/doi/pdf/10.1080/08820139.2022.2096463
Reference44 articles.
1. A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab
2. Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System
3. Chimeric NKG2D Receptor–Bearing T Cells as Immunotherapy for Ovarian Cancer
4. Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors
5. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
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