Clinical trials in pediatric ALS: a TRICALS feasibility study

Author:

Kliest Tessa1,Van Eijk Ruben P.A.12,Al-Chalabi Ammar34ORCID,Albanese Alberto5,Andersen Peter M.6,Amador Maria Del Mar78,BrÅthen Geir910,Brunaud-Danel Veronique11,Brylev Lev1213ORCID,Camu William14,De Carvalho Mamede1516ORCID,Cereda Cristina17,Cetin Hakan18,Chaverri Delia19,Chiò Adriano2021ORCID,Corcia Philippe22ORCID,Couratier Philippe23,De Marchi Fabiola24,Desnuelle Claude25,Van Es Michael A.1,Esteban JesÚs26,Filosto Massimiliano27ORCID,GarcÍa Redondo Alberto26,Grosskreutz Julian28,Hanemann Clemens O.29ORCID,HolmØy Trygve3031,HØyer Helle32,Ingre Caroline3334,Koritnik Blaz35ORCID,Kuzma-Kozakiewicz Magdalena36,Lambert Thomas37,Leigh Peter N.38,Lunetta Christian3940,Mandrioli Jessica4142,Mcdermott Christopher J.43ORCID,Meyer Thomas44,Mora Jesus S.45,Petri Susanne46,Povedano MÓnica47,Reviers Evy48,Riva Nilo49,Roes Kit C.B.50,Rubio Miguel Á.5152,Salachas FranÇois78,Sarafov Stayko53,SorarÙ Gianni54,Stevic Zorica55,Svenstrup Kirsten56,MØller Anette Torvin57,Turner Martin R.58ORCID,Van Damme Philip5960ORCID,Van Leeuwen Lucie A.G.1,Varona Luis61,VÁzquez Costa Juan F.62ORCID,Weber Markus63,Hardiman Orla64,Van Den Berg Leonard H.1

Affiliation:

1. Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands

2. Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands

3. Department of Basic and Clinical Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK

4. Department of Neurology, King’s College Hospital, London, UK

5. IRCCS Humanitas Research Hospital Rozzano, Milan, Italy

6. Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden

7. Département de Neurologie, Centre de référence SLA Ile de France

8. Hôpital de la Pitié Salpêtrière, AP-HP, Paris, France

9. Department of Neurology, University Hospital of Trondheim, Trondheim, Norway

10. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

11. ALS centre, CHU, University of Lille Nord de France, Lille, France

12. Bujanov Moscow City Clinical Hospital, Moscow, Russian Federation

13. Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russian Federation

14. ALS Centre CHU Gui de Chauliac, University of Montpellier, Montpellier, France

15. Institute of Physiology-Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

16. Department of Neurosciences and Mental Health, H Santa Maria-CHLN, Lisbon, Portugal

17. Regional Newborn Screening Laboratory, Vittore Buzzi Children's Hospital-University of Milan, Italy

18. Department of Neurology, Medical University of Vienna, Vienna, Austria

19. Neurology Service, Hospital Universitario La Paz, Madrid, Spain

20. 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy

21. Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy

22. Centre Constitutif SLA, CHRU de Tours - Fédération des centres SLA Tours-Limoges, LitORALS, Tours, France

23. Centre Constitutif de reference SLA-Fédération Tours-Limoges, CHU de Limoges, Limoges, France

24. "Maggiore della Carità" University Hospital, Novara, Italy

25. Hôpital Pasteur 2 – CHU de Nice, Nice, France

26. ALS Research Lab - ALS Unit, Instituto de Investigación Sanitaria Hospital 12 de Octubre "i + 12", CIBERER, Madrid, Spain

27. Department of Clinical and Experimental Sciences, University of Brescia; NeMO-Brescia Clinical Center for Neuromuscular Diseases, Brescia, Italy

28. Precision Neurology, Dept. of Neurology, Lübeck University Hospital, Lübeck, Germany

29. University of Plymouth, Peninsula Schools of Medicine and Dentistry, Plymouth, UK

30. Department of Neurology, Akershus University Hospital, Lørenskog, Norway

31. Institute of Clinical Medicine, University of Oslo, Oslo, Norway

32. Department of Medical Genetics, Telemark Hospital, Skien, Norway

33. Department of Neurology, Karolinska University Hospital, Stockholm, Sweden

34. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

35. Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia

36. Department of Neurology, Medical University of Warsaw, Warsaw, Poland

37. Department of Neurology, Royal Stoke University Hospital, Stoke, United Kingdom

38. Department of Neuroscience, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex, Brighton, UK

39. NEMO Clinical Center, Serena Onlus Foundation, Milan, Italy

40. NEMO LAB, Milan, Italy

41. Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy

42. Department of Neuroscience, St. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy

43. Department of Neuroscience, University of Sheffield, Sheffield Institute for Translational Neuroscience, Sheffield, United Kingdom

44. ALS Outpatient Department, Charité – Universitatsmedizin Berlin, Berlin, Germany

45. ALS Unit/Neurology, Hospital San Rafael, Madrid, Spain

46. Department of Neurology, Hannover Medical School, Hannover, Germany

47. Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, Hospitalet de Llobregat, Spain

48. European Organization for Professionals and Patients with ALS (EUpALS) & ALS Liga Belgium, Leuven, Belgium

49. Department of Neurology, Experimental Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

50. Department of Health Evidence, Section Biostatistics, Radboud University Medical Centre Nijmegen, Nijmegen, the Netherlands

51. Neuromuscular Unit, Department of Neurology, Hospital del Mar, Barcelona, Spain

52. Instituto Hospital del Mar de Investivaciones Médicas (IMIM), Barcelona, Spain

53. Clinic of General Neurology, Medical University Sofia, University Hospital Alexandrovska, Sofia, Bulgaria

54. Department of Neurosciences, University of Padova, Padova, Italy

55. Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia

56. Department of Neurology, Bispebjerg-Frederiksberg Hospital and Rigshospitalet, University Hospital of Copenhagen, Denmark

57. Department of Neurology, Aarhus University Hospital, Aarhus, Denmark

58. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

59. Department of Neurosciences, Laboratory for Neurobiology, KU Leuven and Centre for Brain & Disease Research, VIB, Leuven Brain Institute, Leuven, Belgium

60. Department of Neurology, University Hospitals Leuven, Leuven, Belgium

61. Department of Neurology, Basurto University Hospital, Vizcaya, Spain

62. ALS Unit and Neuromuscular Disease Unit, Department of Neurology, Hospital La Fe, Valencia, Spain

63. Neuromoscular Disease Unit/ALS Clinic, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

64. Academic Unit of Neurology Trinity College Dublin Ireland, Dublin, Ireland

Publisher

Informa UK Limited

Subject

Neurology (clinical),Neurology

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