Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs

Author:

Eldesouky Hassan E.12ORCID,Lanman Nadia A.13ORCID,Hazbun Tony R.4ORCID,Seleem Mohamed N.12ORCID

Affiliation:

1. Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA

2. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

3. Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA

4. Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Immunology,Microbiology,Parasitology

Reference68 articles.

1. Candida auris: An emerging pathogen “incognito”?

2. Candida auris : An emerging multidrug-resistant pathogen

3. CDC. Antibiotic resistance threats in the United States. Atlanta (GA): U.S. Department of Health and Human Services, Antibiotic Resistance Threats in the United States; 2019. (Accessed on 18 April 2020). Available from: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf

4. Synergistic interactions of sulfamethoxazole and azole antifungal drugs against emerging multidrug-resistant Candida auris

5. CDC. Antifungal susceptibility and resistance breakpoints in Candida auris; 2020. (Accessed on 18 April 2020). Available from: https://www.cdc.gov/fungal/candida-auris/c-auris-antifungal.html

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