Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration

Author:

Chen Hai-Wei12ORCID,Liu Ming-Qiang12ORCID,Zhang Guang-Zhi12ORCID,Zhang Cang-Yu12,Wang Zhao-Heng12,Lin Ai-Xin12,Kang Ji-He12,Liu Wen-Zhao12,Guo Xu-Dong12,Wang Yi-Dian12,Kang Xue-Wen1234ORCID

Affiliation:

1. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China

2. The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China

3. Key Laboratory of Orthopedics Disease of Gansu Province, Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China

4. The International Cooperation Base of Gansu Province for the Pain Research in Spinal Disorders, Lanzhou, Gansu, China

Funder

the special fund project for doctoral training programme of Lanzhou University Second Hospital

and the Chinese Medicine Administration Research Project of Gansu province

the Cuiying Technology Innovation Project of Lanzhou University Second Hospital

Lanzhou University Innovation and Entrepreneurship Cultivation Project

The Natural Science Foundation of Gansu Province

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology,Orthopedics and Sports Medicine,Biochemistry,Rheumatology

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