Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia – first findings of the OPAL trial

Author:

Krull Kathinka1,Kunstreich Marina1,Klasen-Sansone Janina2,Kloetgen Andreas13,Gruener Franziska4,Escherich Gabriele4,Bleckmann Kirsten5,Moericke Anja5,Schrappe Martin5,Jorch Norbert6,Steinbach Daniel7,Classen Carl-Friedrich8,Guggemos Andreas9,Kolb Reinhard10,Klee Dirk2,Borkhardt Arndt1,Kuhlen Michaela1ORCID

Affiliation:

1. Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, University of Duesseldorf, Duesseldorf, Germany;

2. Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany;

3. Department of Pathology, NYU School of Medicine, New York, NY, USA;

4. Clinic of Pediatric Hematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany;

5. Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany;

6. Department of Pediatrics, Evangelical Hospital, Bielefeld, Germany;

7. Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany;

8. Department of Pediatrics, University Hospital Rostock, Rostock, Germany;

9. Department of Pediatric Oncology/Hematology, Children’s Hospital Cologne, Cologne, Germany;

10. Pediatric Hematology and Oncology, Elisabeth-Hospital Oldenburg, Oldenburg, Germany

Funder

German Childhood Cancer Foundation

Publisher

Informa UK Limited

Subject

Cancer Research,Oncology,Hematology

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