Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

Author:

Theunissen Peter T.,Beken Sonja,Beyer Bruce K.,Breslin William J.,Cappon Gregg D.,Chen Connie L.,Chmielewski Gary,De Schaepdrijver Luc,Enright Brian,Foreman Jennifer E.,Harrouk Wafa,Hew Kok-Wah,Hoberman Alan M.,Hui Julia Y.,Knudsen Thomas B.,Laffan Susan B.,Makris Susan L.,Martin Matt,McNerney Mary Ellen,Siezen Christine L.,Stanislaus Dinesh J.,Stewart Jane,Thompson Kary E.,Tornesi Belen,Van der Laan Jan Willem,Weinbauer Gerhard F.,Wood Sandra,Piersma Aldert H.

Funder

SLIM project, by the Dutch Government, Dept. Econimical Affairs; The Utrecht Province and The Utrecht City Administration

ILSI HESI

Publisher

Informa UK Limited

Subject

Toxicology

Reference22 articles.

1. Effects of feed restriction during organogenesis on embryo-fetal development in rabbit

2. Cappon GD, Theunissen PT, Beken S, Beyer BK, Breslin WJ, Chen CL, Chmielewski G, De Schaepdrijver L, Enright B, Foreman JE, et al. Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: Implications for human risk assessment. (In preparation).

3. CDC. (2015). Congenital heart defects (CHDs): data & statistics. Atlanta, GA, USA. Available from: http://www.cdc.gov/ncbddd/heartdefects/data.html.

4. Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals

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