Matrine Inhibitory Effect on Self-renewal and Re-sensitization of 5-FU Resistant NSCLC Stem Cells were through Let-7b dependent Downregulation of CCND1

Author:

Li Xiang1,Wang Meng1,Du Ning1,Liang Ting23,Xiao Guo-Dong14ORCID,Li Kai1,Wang Ji-Chang5,Xu Chong-Wen6,Peng Zi-Yang1,Tang Shou-Ching7,Sun Xin1ORCID

Affiliation:

1. Department of Thoracic Surgery and Oncology, The Second Department of Thoracic Surgery, Cancer Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R.China

2. Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R.China

3. Department of Biomedical Engineering, The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an, Shaanxi, P.R.China

4. Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R.China

5. Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R.China

6. Department of Otorhinolaryngology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R.China

7. University of Mississippi Medical Center, Cancer Center and Research Institute, University of Mississippi, Jackson, Mississippi, USA.

Funder

National Science Foundation for Young Scientists of China

Foundation Research Project of Shaanxi Province

Publisher

Informa UK Limited

Subject

Cell Biology,Developmental Biology,Molecular Biology

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