Imipridone family on successful TRAIL
Author:
Affiliation:
1. Pediatric Hematology/Oncology/BMT and Radiation Oncology, Pediatric Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
Publisher
Informa UK Limited
Subject
Cell Biology,Developmental Biology,Molecular Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/15384101.2017.1345237
Reference6 articles.
1. Discovery and clinical introduction of first-in-class imipridone ONC201
2. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
3. ONC201 Exerts p53-Independent Cytotoxicity Through TRAIL and DR5 Induction In Mantle Cell Lymphomas
4. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner
5. First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
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1. The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia;Cancer Research;2024-01-24
2. Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor;Clinical Cancer Research;2022-01-11
3. Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10;Frontiers in Pharmacology;2021-10-21
4. Targeting TRAIL;Bioorganic & Medicinal Chemistry Letters;2019-09
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