Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival

Author:

Sobral-Leite Marcelo12ORCID,Van de Vijver Koen3ORCID,Michaut Magali4ORCID,van der Linden Rianne3,Hooijer Gerrit K.J.5,Horlings Hugo M.3ORCID,Severson Tesa M.4ORCID,Mulligan Anna Marie67,Weerasooriya Nayana8ORCID,Sanders Joyce3ORCID,Glas Annuska M9ORCID,Wehkamp Diederik9,Mittempergher Lorenza9,Kersten Kelly10,Cimino-Mathews Ashley11,Peters Dennis12,Hooijberg Erik3ORCID,Broeks Annegien12,van de Vijver Marc J.5,Bernards Rene4ORCID,Andrulis Irene L.71314,Kok Marleen1516ORCID,de Visser Karin E.9ORCID,Schmidt Marjanka K.1ORCID

Affiliation:

1. Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands

2. Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil

3. Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands

4. Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands

5. Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

6. Laboratory Medicine Program, University Health Network, Toronto, ON, Canada

7. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

8. University Health Network, Toronto, ON, Canada

9. Agendia NV, Science Park, Amsterdam, The Netherlands

10. Division of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands

11. Departments of Pathology and Oncology, The Johns Hopkins Hospital, Baltimore, USA

12. Core Facility Molecular Pathology and Biobanking, Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands

13. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada

14. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

15. Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands

16. Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

Funder

European Commission

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior

HHS | National Institutes of Health

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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