S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity

Author:

Zhang Jinhua1ORCID,Song Kun12,Wang Jun3,Li Yanan12,Liu Shuangqing12,Dai Chengliang12,Chen Lieping3ORCID,Wang Shengdian4,Qin Zhihai15

Affiliation:

1. Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Department of Immunobiology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA

4. Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

5. Medical Research Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

Funder

National Natural Science Foundation of China (NSFC)

Ministry of Science and Technology of China

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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