Immunogenicity and safety of different schedules of the meningococcal ABCWY vaccine, with assessment of long-term antibody persistence and booster responses – results from two phase 2b randomized trials in adolescents

Author:

Vesikari Timo1,Brzostek Jerzy2,Ahonen Anitta3,Paassilta Marita4,Majda-Stanislawska Ewa5,Szenborn Leszek6ORCID,Virta Miia3,Clifford Robert7ORCID,Jackowska Teresa8,Kimmel Murray9,Bindi Ilaria10,Keshavan Pavitra10,Pedotti Paola11,Toneatto Daniela10ORCID

Affiliation:

1. Nordic Research Network Oy, Tampere, Finland

2. Health Care Establishment in Debica, Infectious Diseases Outpatient Clinic, Debica, Poland

3. Vaccine Research Center, Tampere University, Tampere, Finland

4. Tampere University and Tampere University Hospital, Tampere, Finland

5. Department of Pediatric Infectious Diseases, Medical University of Lodz, Lodz, Poland

6. Department of Pediatric Infectious Diseases, Wroclaw Medical University, Wroclaw, Poland

7. Coastal Pediatric Research, Charleston, SC, USA

8. Department of Pediatrics, The Medical Centre of Postgraduate Education, Warsaw, Poland

9. Optimal Research LLC, Melbourne, FL, USA

10. Gsk, Siena, Italy

11. Gsk, Amsterdam, The Netherlands

Funder

GSK group of companies

Publisher

Informa UK Limited

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference52 articles.

1. World Health Organization. Meningococcal meningitis. Key facts. 2018 Feb 19 [accessed 2019 Feb]. https://www.who.int/en/news-room/fact-sheets/detail/meningococcal-meningitis.

2. Centers for Disease Control and Prevention. Enhanced meningococcal disease surveillance report, 2017. 2019 May 31 [accessed 2020 Feb]. https://www.cdc.gov/meningococcal/downloads/NCIRD-EMS-Report-2017.pdf.

3. European Center for Disease Prevention and Control. Surveillance report. annual epidemiological report for 2016. Invasive meningococcal disease. Stockholm; 2018.

4. European Center for Disease Prevention and Control. Factsheet about meningococcal disease. 2019 Jan 7 [accessed 2019 Feb]. https://ecdc.europa.eu/en/meningococcal-disease/factsheet.

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