Expanding the therapeutic arsenal against cancer: a computational investigation of hybrid xanthone derivatives as selective Topoisomerase 2α ATPase inhibitors-Reference-Cited by-同舟云学术

Expanding the therapeutic arsenal against cancer: a computational investigation of hybrid xanthone derivatives as selective Topoisomerase 2α ATPase inhibitors

Published:2023-11-17 Issue: Volume: Page:1-30
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Gogoi Urvashee¹^ORCID,Gogoi Neelutpal¹^ORCID,Rajkhowa Sanchaita²^ORCID,Khan Shah Alam³^ORCID,Daffa Alla Omer Hajedris Nisreen⁴⁵^ORCID,Al-Hoshani Nawal⁶^ORCID,Al-Shouli Samia T.⁷^ORCID,Das Aparoop¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Faculty of Science & Engineering, Dibrugarh University, Dibrugarh, Assam, India

2. Centre for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh, Assam, India

3. College of Pharmacy, National University of Science and Technology, Muscat, Oman

4. College of Medicine, Basic Medical Department, Almaarefa University, Riyadh, Saudi Arabia

5. Faculty of Medicine, Department of Physiology, Khartoum University, Khartoum, Sudan

6. Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

7. Immunology Unit, Pathology department, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia

Funder

All India Council for Technical Education

Princess Nourah bint Abdulrahman University Researchers Supporting Project number

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2023.2280723

Reference52 articles.

1. QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα

2. New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies

3. In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking, ADMET, Toxicity and DFT Studies

4. Synthesis of 2,7-diarylpyrazolo [1,5-a] pyrimidine derivatives with antitumor activity. Theoretical identification of targets

5. N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase