Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS-Reference-Cited by-同舟云学术

Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS

Published:2021-12-02 Issue:12 Volume:51 Page:1389-1399
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Qin Yan¹,Dong Haijun¹²,Sun Jiayin¹,Zhang Yilong¹,Li Jun¹,Zhang Tianci¹,Chen Guanjun³,Wang Sheng³,Song Shuai¹⁴,Wang Wei¹⁵,Fan Yuru¹⁶,Wang Jie¹,Huang Xiaohui¹,Shen Chenlin¹⁷

Affiliation:

1. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Institute for Liver Diseases of Anhui Medical University, Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, China

2. Nanjing cantech Microbial Sci.& Tech. Co., Ltd, Nanjing, China

3. Center for Scientific Research of Anhui Medical University, Hefei, P.R. China

4. Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

5. Genrix (Shanghai) Biopharmaceutical Co., Ltd, Shanghai, P.R. China

6. Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, China

7. Hefei Kaifan Analytical Technology Co., Ltd, Hefei, China

Funder

the National Natural Science Foundation of China

the First Affiliated Hospital of Anhui Medical University for the Cultivation Program of Youth Science Foundation

Innovation and Entrepreneurship Training Program for Undergraduates of Anhui Medical University

the Fund of Anhui Medical University Doctoral Start Research

Grants for Scientific Research of BSKY from Anhui Medical University

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.2009934

Reference36 articles.

1. Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution

2. Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations

3. Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions

4. Studies on the metabolism and degradation of vancomycin in simulated in vitro and aquatic environment by UHPLC-Triple-TOF-MS/MS

5. Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain

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