Inhibitory potentials of phytocompounds from <i>Ocimum gratissimum</i> against anti-apoptotic BCL-2 proteins associated with cancer: an integrated computational study-Reference-Cited by-同舟云学术

Inhibitory potentials of phytocompounds from Ocimum gratissimum against anti-apoptotic BCL-2 proteins associated with cancer: an integrated computational study

Published:2022-09-20 Issue:1 Volume:9 Page:588-608
ISSN:2314-808X
Container-title:Egyptian Journal of Basic and Applied Sciences
language:en
Short-container-title:Egyptian Journal of Basic and Applied Sciences

Author:

A. Gyebi Gideon¹²^ORCID,M. Ogunyemi Oludare³,M. Ibrahim Ibrahim⁴,O. Afolabi Saheed⁵,J. Ojo Rotimi¹,D.I. Ejike Uju¹,O. Adebayo Joseph⁶

Affiliation:

1. Department of Biochemistry, Faculty of Science and Technology Bingham University, Karu, Nigeria

2. Natural Products and Structural (Bio-Chem)-informatics Computing Research Laboratory (NpsBC-Cr),sDepartment of Biochemistry, Bingham University, Karu, Nasarawa, Nigeria

3. Human Nutraceuticals and Bioinformatics Unit, Department of Biochemistry, Sciences, Salem University, Lokoja, Nigeria

4. Department of Biophysics, Faculty of Sciences, Cairo University, Giza, Egypt

5. Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria

6. Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria

Funder

did not receive any funding

Publisher

Informa UK Limited

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/2314808X.2022.2106095

Reference68 articles.

1. Molecular dynamic simulations on an inhibitor of anti-apoptotic Bcl-2 proteins for insights into its interaction mechanism for anti-cancer activity

2. Solution structure of the antiapoptotic protein bcl-2

3. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

4. Phytosterols and triterpenes from Morinda lucida Benth (Rubiaceae) as potential inhibitors of anti-apoptotic BCL-XL, BCL-2, and MCL-1: an in-silico study

5. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity