CRISPR-based rapid and ultra-sensitive diagnostic test for Mycobacterium tuberculosis

Author:

Ai Jing-Wen1,Zhou Xian1,Xu Teng2,Yang Minling2,Chen Yuanyuan3,He Gui-Qing4,Pan Ningp4,Cai Yuwei4,Li Yongjun2,Wang Xiaorui2,Su Hang2,Wang Ting5,Zeng Weiqi2,Zhang Wen-Hong1

Affiliation:

1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

2. Vision Medicals Co., Ltd, Guangzhou, People’s Republic of China

3. Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China

4. Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, People’s Republic of China

5. Department of Infectious Diseases, Jing’an District Central Hospital of Shanghai, Shanghai, People’s Republic of China

Funder

Key Technologies Research and Development Program

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference22 articles.

1. Organization WH. Global Tuberculosis Report 2017. World Health Organization; 2018.

2. WHO. Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. Department/Division; 2011.

3. Tuberculosis: advances and challenges in development of new diagnostics and biomarkers

4. CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity

5. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

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