The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage

Author:

Liang Ronghui1,Ye Zi-Wei1ORCID,Ong Chon Phin2,Qin Zhenzhi1,Xie Yubin1,Fan Yilan2,Tang Kaiming1,Poon Vincent Kwok-Man13,Chan Chris Chung-Sing13,Yang Xiaomeng1,Cao Hehe1,Wang Kun1,Sun Haoran4,Hu Bodan1,Cai Jian-Piao1,Luo Cuiting1,Chik Kenn Ka-Heng14,Chu Hin134ORCID,Zheng Yi5,Yuen Kwok-Yung13467ORCID,Chan Jasper Fuk-Woo13467ORCID,Jin Dong-Yan238ORCID,Yuan Shuofeng134ORCID

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

2. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

3. Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Shatin, Hong Kong Special Administrative Region, People’s Republic of China

4. Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of China

5. Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

6. Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

7. Academician Workstation of Hainan Province, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People’s Republic of China

8. Guangzhou Laboratory, Guangdong Province, People’s Republic of China

Funder

Food and Health Bureau

Theme-Based Research Scheme of the Research Grants Council

National Key Research and Development Program of China

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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