Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies

Author:

Piermatteo Lorenzo12,D’Anna Stefano2,Bertoli Ada2,Bellocchi Maria2,Carioti Luca2,Fabeni Lavinia3,Alkhatib Mohammad2,Frazia Simone La1,Lichtner Miriam4,Mastroianni Claudio4,Sanctis Giuseppe De5,Marignani Massimo6,Pasquazzi Caterina6,Iapadre Nerio7,Parruti Giustino8,Cappiello Giuseppina9,Vecchiet Jacopo10,Malagnino Vincenzo11,Grelli Sandro212,Ceccherini-Silbertein Francesca2,Andreoni Massimo11,Sarmati Loredana11,Svicher Valentina1,Salpini Romina1

Affiliation:

1. Department of Biology, Tor Vergata University, Rome, Italy

2. Department of Experimental Medicine, Tor Vergata University, Rome, Italy

3. National Institute for Infectious Disease, IRCCS L. Spallanzani, Virology and Biosafety Laboratories Unit, Rome, Italy

4. Department of Public Health and Infectious Disease, “Sapienza” University, Rome, Italy

5. “Umberto I” University Hospital, Rome, Italy

6. Department of Gastroenterology, “S. Andrea Hospital”, Rome, Italy

7. “San Salvatore Hospital”, L’Aquila, Italy

8. Infectious Diseases Unit, Pescara General Hospital, Pescara, Italy

9. Microbiology and Virology Unit, “S. Pertini” Hospital, Rome, Italy

10. Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University “G. d'Annunzio” Chieti-Pescara, Chieti, Italy

11. Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy

12. Virology Unit, Tor Vergata University Hospital, Rome, Italy

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference41 articles.

1. WHO. Global progress report on HIV viral sexually transmitted infections. World Health Organization; 2021 [cited 2022 Oct 21]. Available from: https://www.who.int/publications/i/item/9789240027077.

2. Global Elimination of Chronic Hepatitis

3. HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals

4. Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose

5. Overview of hepatitis B viral replication and genetic variability

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