In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates

Author:

Patel Ami1,Rosenke Kyle2,Parzych Elizabeth M.1,Feldmann Friederike2,Bharti Suman1,Griffin Amanda J.2,Schouest Blake3,Lewis Matt2,Choi Jihae1,Chokkalingam Neethu1,Machado Viviane3,Smith Brian J.2,Frase Drew1,Ali Ali R.1,Lovaglio Jamie2,Nguyen Brian3,Hanley Patrick W.2,Walker Susanne N.1,Gary Ebony N.1,Kulkarni Abhijeet1,Generotti Allison3,Francica Joseph R.4,Rosenthal Kim4,Kulp Daniel W.1,Esser Mark T4,Smith Trevor R.F.3,Shaia Carl2ORCID,Weiner David B1,Feldmann Heinz2ORCID

Affiliation:

1. Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, USA

2. Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

3. Inovio Pharmaceuticals, Plymouth Meeting, PA, USA

4. Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA

Funder

Defense Sciences Office, DARPA

National Institutes of Health

The Jill and Mark Fishman Foundation

W. W. Smith Charitable Trust

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference41 articles.

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