A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants-Reference-Cited by-同舟云学术

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants

Published:2023-08-23 Issue:2 Volume:12 Page:
ISSN:2222-1751
Container-title:Emerging Microbes & Infections
language:en
Short-container-title:Emerging Microbes & Infections

Author:

Pérez-Vargas Jimena¹^ORCID,Worrall Liam J.²^ORCID,Olmstead Andrea D.¹^ORCID,Ton Anh-Tien³^ORCID,Lee Jaeyong²⁴,Villanueva Ivan¹^ORCID,Thompson Connor A. H.¹,Dudek Svenja¹,Ennis Siobhan⁵^ORCID,Smith Jason R.³⁶^ORCID,Shapira Tirosh¹,De Guzman Joshua¹,Gang Shutong¹,Ban Fuqiang³,Vuckovic Marija²^ORCID,Bielecki Michael⁶,Kovacic Suzana⁶,Kenward Calem²^ORCID,Hong Christopher Yee¹,Gordon Danielle G.¹,Levett Paul N.⁷⁸^ORCID,Krajden Mel⁷⁸,Leduc Richard⁹^ORCID,Boudreault Pierre-Luc⁹^ORCID,Niikura Masahiro⁵^ORCID,Paetzel Mark⁴^ORCID,Young Robert N.⁶^ORCID,Cherkasov Artem³^ORCID,Strynadka Natalie C. J.²^ORCID,Jean François¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada

2. Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, Canada

3. Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada

4. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada

5. Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada

6. Department of Chemistry, Simon Fraser University, Burnaby, Canada

7. British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, Canada

8. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

9. Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada

Funder

Canadian Institutes of Health Research

Genome British Columbia

Mitacs

Coronavirus Variants Rapid Response Network

MITACS Inc. Accelerate fellowship COVID-19 Award

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Link

https://www.tandfonline.com/doi/pdf/10.1080/22221751.2023.2246594