HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts

Author:

Jang Seung-Gyu1ORCID,Kim Young-Il2ORCID,Casel Mark Anthony B.13ORCID,Choi Jeong Ho1ORCID,Gil Ju Ryeon1ORCID,Rollon Rare1ORCID,Kim Eun-Ha2ORCID,Kim Se-Mi2ORCID,Ji Ho Young2ORCID,Park Dong Bin2ORCID,Hwang Jungwon4ORCID,Ahn Jae-Woo2ORCID,Kim Myung Hee4ORCID,Song Min-Suk13ORCID,Choi Young Ki123ORCID

Affiliation:

1. College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

2. Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

3. Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea

4. Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Funder

Institute for Basic Science

National Research Foundation of Korea

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference54 articles.

1. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus;Claas EC;Lancet,1998

2. Avian influenza and human health;Capua I;Acta Trop,2002

3. Avian influenza infections in birds - a moving target;Capua I;Influenza Other Resp,2007

4. Poultry and the influenza H5N1 outbreak in Hong Kong, 1997. Abridged chronology and virus isolation;Shortridge KF.;Vaccine,1999

5. HPAI H5N1 situation in Europe and potential risk factors for the introduction of the virus to the United Kingdom;Sabirovic MH;Defra,2006

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