Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Author:

Chen Yanxia1,Li Can12,Liu Feifei1,Ye Zhanhong1,Song Wenchen12,Lee Andrew C. Y.12,Shuai Huiping1,Lu Lu1,To Kelvin Kai-Wang1324ORCID,Chan Jasper Fuk-Woo13245ORCID,Zhang Anna Jinxia12ORCID,Chu Hin124ORCID,Yuen Kwok-Yung13245ORCID

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

2. Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Sha Tin, Hong Kong Special Administrative Region, People’s Republic of China

3. Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

4. Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People’s Republic of China

5. Academician Workstation of Hainan Province and Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People’s Republic of China

Funder

Health and Medical Research Fund

Food and Health Bureau, The Government of the Hong Kong Special Administrative Region

General Research Fund

The Government of the Hong Kong Special Administrative Region

Innovation and Technology Commission , the Government of the Hong Kong Special Administrative Region

National Natural Science Foundation of China

University of Hong Kong

National Program on Key Research Project of China

Department of Health of the Hong Kong Special Administrative Region Government

Sanming Project of Medicine in Shenzhen

Health Commission of Guangdong Province, China

Hainan Academician Innovation Platform

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference42 articles.

1. World Health Organization. Weekly epidemiological update – 28 December 2021. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20211228_weekly_epi_update_72.pdf?sfvrsn = 7a3567d4_3&download = true.

2. Evidence for SARS-CoV-2 Infection of Animal Hosts

3. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

4. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

5. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

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