PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA

Author:

Xu Yingying12ORCID,Zheng Yijing1,Ding Xuqiu3,Wang Chengyan4,Hua Bin1,Hong Shilian1,Huang Xiaoman1,Lin Jiali1,Zhang Peng5ORCID,Chen Wei6ORCID

Affiliation:

1. School of Pharmacy, Fujian Medical University, Fuzhou, China

2. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China

3. School of Clinical Medicine, Fujian Medical University, Fuzhou, China

4. Institute of Laboratory Animal Center, Fujian Medical University, Fuzhou, China

5. Department of Pharmacy, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen, China

6. Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou, China

Funder

National Natural Science Foundation of China

Fujian Provincial Natural Science Foundation of China

MEL Visiting Fellowship of State Key Laboratory of Marine Environmental Science

Startup Fund for scientific research of Fujian Medical University

Publisher

Informa UK Limited

Subject

Pharmaceutical Science,General Medicine

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