Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C <sub>H</sub> 1-C <sub>λ</sub> interface-Reference-Cited by-同舟云学术

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Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C _H 1-C _λ interface

Published:2023-11-06 Issue:1 Volume:15 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Bagert John D.¹,Oganesyan Vaheh¹,Chiang Chi-I¹,Iannotti Mike¹,Lin Jia¹,Yang Chunning¹,Payne Sterling¹,McMahon Will²,Edwards Samuel²,Dippel Andrew¹,Hutchinson Mark¹,Huang Fengying¹,Aleti Vineela¹,Niu Chendi¹,Qian Chen¹,Denham Jessica¹,Ferreira Sofia³,Pradhan Pallab¹,Penney Mark³,Wang Chunlei¹,Liu Wenhai¹,Walseng Even¹,Mazor Yariv¹

Affiliation:

1. Biologics Engineering, AstraZeneca, Gaithersburg, MD, USA

2. Process and Analytical Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA

3. Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK

Funder

U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences

Structural Molecular Biology Program

National Institutes of Health, National Institute of General Medical Sciences

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2273449

Reference33 articles.

1. Alternative molecular formats and therapeutic applications for bispecific antibodies

2. Bispecific antibodies

3. Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence

4. The evolution of bispecific antibodies

5. Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

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