Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb-Reference-Cited by-同舟云学术

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Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb

Published:2020-01-01 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Lan Wenkui¹,Valente Joseph J.¹,Ilott Andrew¹,Chennamsetty Naresh²,Liu Zhihua¹,Rizzo Joseph M.³,Yamniuk Aaron P.³,Qiu Difei⁴,Shackman Holly M.⁴,Bolgar Mark S.¹

Affiliation:

1. Drug Product Development, Bristol Myers Squibb, New Brunswick, United States

2. Biophysics Center of Excellence, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, United States

3. Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States

4. Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2020.1763138

Reference69 articles.

1. Probing the diverse landscape of protein flexibility and binding

2. Enzyme flexibility and enzyme action

3. Intrinsic dynamics of an enzyme underlies catalysis

4. The Complex Inter-Relationships Between Protein Flexibility and Stability

5. The Energy Landscapes and Motions of Proteins

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1. In silico prediction of post-translational modifications in therapeutic antibodies;mAbs;2022-01-18

2. Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups;2021-06-11

3. Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography;Biotechnology and Bioengineering;2021-05-27

4. Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study;Biomolecules;2021-02-23

5. Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups;Computational and Structural Biotechnology Journal;2021

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