Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom

Author:

Spelman T.12ORCID,Herring W. L.34ORCID,Acosta C.5ORCID,Hyde R.6,Jokubaitis V. G.7ORCID,Pucci E.8,Lugaresi A.910,Laureys G.11,Havrdova E. K.12,Horakova D.12,Izquierdo G.13,Eichau S.13,Ozakbas S.14,Alroughani R.15,Kalincik T.1617,Duquette P.18,Girard M.18,Petersen T.19,Patti F.2021ORCID,Csepany T.22ORCID,Granella F.2324,Grand’Maison F.25,Ferraro D.26,Karabudak R.27,Jose Sa M.2829,Trojano M.30,van Pesch V.3132,Van Wijmeersch B.33,Cartechini E.34,McCombe P.3536,Gerlach O.3738,Spitaleri D.39,Rozsa C.40,Hodgkinson S.41,Bergamaschi R.42,Gouider R.4344,Soysal A.45,Castillo-Triviño 46,Prevost J.47,Garber J.48,de Gans K.49,Ampapa R.50,Simo M.51,Sanchez-Menoyo J. L.5253,Iuliano G.54,Sas A.55,van der Walt A.756,John N.5758,Gray O.59,Hughes S.60,De Luca G.61,Onofrj M.62,Buzzard K.636465,Skibina O.566466,Terzi M.67,Slee M.68,Solaro C.6970,Oreja-Guevara 71,Ramo-Tello C.72,Fragoso Y.73,Shaygannejad V.74,Moore F.75,Rajda C.76,Aguera Morales E.7778,Butzkueven H.7

Affiliation:

1. MSBase Foundation, Melbourne, VIC, Australia

2. Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

3. Health Economics, RTI Health Solutions, NC, USA

4. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden

5. Value and Access, Biogen, Baar, Switzerland

6. Medical, Biogen, Baar, Switzerland

7. Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia

8. Neurology Unit, AST-Fermo, Fermo, Italy

9. Dipartamento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy

10. IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

11. Department of Neurology, University Hospital Ghent, Ghent, Belgium

12. Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

13. Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain

14. Izmir University of Economics, Medical Point Hospital, Izmir, Turkey

15. Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait

16. Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia

17. CORe, Department of Medicine, University of Melbourne, Melbourne, Australia

18. CHUM and Universite de Montreal, Montreal, Canada

19. Aarhus University Hospital, Arhus C, Denmark

20. Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, Catania, Italy

21. UOS Sclerosi Multipla, AOU Policlinico “G Rodloico-San Marco”, University of Catania, Italy

22. Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

23. Department of Medicine and Surgery, University of Parma, Parma, Italy

24. Department of General Medicine, Parma University Hospital, Parma, Italy

25. Neuro Rive-Sud, Quebec, Canada

26. Department of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italy

27. Hacettepe University, Ankara, Turkey

28. Department of Neurology, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal

29. Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal

30. School of Medicine, University of Bari, Bari, Italy

31. Cliniques Universitaires Saint-Luc, Brussels, Belgium

32. Université Catholique de Louvain, Belgium

33. University MS Centre, Hasselt-Pelt and Noorderhart Rehabilitation & MS, Pelt and Hasselt University, Hasselt, Belgium

34. Neurology unit, AST Macerata, Macerata, Italy

35. University of Queensland, Brisbane, Australia

36. Royal Brisbane and Women’s Hospital, Herston, Australia

37. Academic MS Center Zuyd, Department of Neurology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands

38. School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands

39. Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino, Avellino, Italy

40. Jahn Ferenc Teaching Hospital, Budapest, Hungary

41. Immune Tolerance Laboratory Ingham Institute and Department of Medicine, UNSW, Sydney, Australia

42. IRCCS Mondino Foundation, Pavia, Italy

43. Department of Neurology, LR18SP03 and Clinical Investigation Center Neurosciences and Mental Health, Razi University Hospital –, Mannouba, Tunis, Tunisia

44. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

45. Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey

46. Hospital Universitario Donostia and IIS Biodonostia, San Sebastián, Spain

47. CSSS Saint-Jérôme, Saint-Jerome, Canada

48. Westmead Hospital, Sydney, Australia

49. Groene Hart Ziekenhuis, Gouda, Netherlands

50. Nemocnice Jihlava, Jihlava, Czech Republic

51. Department of Neurology, Semmelweis University Budapest, Budapest, Hungary

52. Department of Neurology, Galdakao-Usansolo University Hospital, Osakidetza Basque Health Service, Galdakao, Spain

53. Biocruces-Bizkaia Health Research Institute, Spain

54. Ospedali Riuniti di Salerno, Salerno, Italy

55. Department of Neurology and Stroke, BAZ County Hospital, Miskolc, Hungary

56. Department of Neurology, The Alfred Hospital, Melbourne, Australia

57. Monash University, Clayton, Australia

58. Department of Neurology, Monash Health, Clayton, Australia

59. South Eastern HSC Trust, Belfast, United Kingdom

60. Royal Victoria Hospital, Belfast, United Kingdom

61. MS Centre, Neurology Unit, “SS. Annunziata” University Hospital, University “G. d’Annunzio”, Chieti, Italy

62. Department of Neuroscience, Imaging, and Clinical Sciences, University G. d’Annunzio, Chieti, Italy

63. Department of Neurosciences, Box Hill Hospital, Melbourne, Australia

64. Monash University, Melbourne, Australia

65. MS Centre, Royal Melbourne Hospital, Melbourne, Australia

66. Department of Neurology, Box Hill Hospital, Melbourne, Australia

67. Medical Faculty, 19 Mayis University, Samsun, Turkey

68. Flinders University, Adelaide, Australia

69. Department of Neurology, ASL3 Genovese, Genova, Italy

70. Department of Rehabilitation, ML Novarese Hospital Moncrivello

71. Department of Neurology, Hospital Clinico San Carlos, Madrid, Spain

72. Department of Neuroscience, Hospital Germans Trias i Pujol, Badalona, Spain

73. Universidade Metropolitana de Santos, Santos, Brazil

74. Isfahan University of Medical Sciences, Isfahan, Iran

75. Department of Neurology, McGill University, Montreal, Canada

76. Department of Neurology, University of Szeged, Szeged, Hungary

77. Department of Medicine and Surgery, University of Cordoba, Cordoba, Spain

78. Maimonides Biomedical Research Institute of Cordoba (IMIBIC)

Funder

Biogen

Publisher

Informa UK Limited

Subject

Health Policy

Reference70 articles.

1. Bainbridge JR, Corboy JR. Multiple sclerosis. In: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey ML, editors. Pharmacotherapy: a pathophysiologic approach. 7th ed. New York: McGraw-Hill Companies, Inc.; 2008.

2. Comparative efficacy of fingolimod vs natalizumab

3. Natalizumab versus fingolimod in patients with relapsing-remitting multiple sclerosis non-responding to first-line injectable therapies

4. The Economic Burden of Multiple Sclerosis in the United States

5. Natalizumab (tysabri) for the treatment of adults with highly active relapsing remitting multiple sclerosis;Biogen Idec UK;Single Technology Appraisal (STA) Submission to the National Institute for Health and Clinical Excellence. NICE Manufacturer’s Submission,2007

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