Therapeutic mechanism of combined oral chelation therapy to maximize efficacy of iron removal in transfusion-dependent thalassemia major

Therapeutic mechanism of combined oral chelation therapy to maximize efficacy of iron removal in transfusion-dependent thalassemia major – a pilot study

Published:2019-03-28 Issue:4 Volume:12 Page:265-272
ISSN:1747-4086
Container-title:Expert Review of Hematology
language:en
Short-container-title:Expert Review of Hematology

Author:

Lin Chien-Heng¹²,Chen Xianxiu³,Wu Chin-Ching³,Wu Kang-Hsi⁴,Song Ta-Shu⁵⁶,Weng Te-Fu⁴,Hsieh Yow-Wen⁷,Peng Ching-Tien⁴⁸

Affiliation:

1. Division of Pediatric Pulmonology, China Medical University Children’s Hospital, Taichung, Taiwan

2. Department of Biomedical Imaging and Radiological Science, College of Health Care, China Medical University, Taichung, Taiwan

3. Department of Public Health, China Medical University, Taichung, Taiwan

4. Division of Pediatric Hematology and Oncology, China Medical University Children’s Hospital, Taichung, Taiwan

5. School of Pharmacy, China Medical University, Taichung, Taiwan

6. Research Department, Yung Shin Pharmaceutical Industrial Co.., Taichung, Taiwan

7. Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan

8. Department of Biotechnology, Asia University, Taichung, Taiwan

Funder

China Medical University Hospital

Publisher

Informa UK Limited

Subject

Hematology

Link

https://www.tandfonline.com/doi/pdf/10.1080/17474086.2019.1593823

Reference22 articles.

1. Prevalence of iron overload complications among patients with β-thalassemia major treated at Dubai Thalassemia Centre

2. Combined iron chelation therapy

3. A Randomized, Placebo-Controlled, Double-Blind Trial of the Effect of Combined Therapy With Deferoxamine and Deferiprone on Myocardial Iron in Thalassemia Major Using Cardiovascular Magnetic Resonance

4. Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone

5. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture

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