Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study

Author:

Li Cuiyun1,Wu Min1,Zhang Hong1,Zhu Xiaoxue1,Fu Li2,Wang Shuo2,Lu Mingming2,Zhong Dafang3,Ding Yanhua1

Affiliation:

1. Phase I Clinical Trial Unit, First Hospital, Jilin University, Changchun, China

2. Dalian Fusheng Institute of Natural Medicine, Dalian, China

3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Funder

Dalian Fusheng Institute of Natural Medicine

Publisher

Informa UK Limited

Subject

General Medicine

Reference20 articles.

1. WHO. Estimate of influenza deaths due to respiratory disease [cited 2021 Oct 13]. Available from: https://www.who.int/teams/global-influenza-programme/surveillance-and-monitoring/ burden-of-disease.

2. Seasonal Influenza (Flu)

3. Antiinflammatory Effect of Forsythia suspensa V AHL and Its Active Fraction.

4. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Beijing: China Medical Science Press; 2015.

5. Evaluating the safety of forsythin from Forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models

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